Appendix 3: Additional outcomes of the analyses

Table A.3.1. Discounted costs and discounted life-years gained per 1000 65-year olds and average cost-effectiveness ratios, by CRC screening scenario—MISCAN

Scenario Discounted Costs, $ Net Discounted Costs, $ Discounted LYG ACER, $/LYG
No screening 2,714,556 0 0 NA
HII 2,631,879 -82,677 65.7 CS
HS 2,715,683 1,127 81.1 14
FIT 2,777,228 62,672 80.1 782
SIGB 2,823,217 108,661 75.0 1,450
SIG 2,810,249 95,693 76.7 1,247
HII + SIGB 2,790,651 76,095 84.9 896
HII + SIG 2,839,118 124,562 85.4 1,459
HS + SIGB 2,907,440 145,259 88.0 1,651
HS + SIG 2,859,815 192,884 87.9 2,194
FIT + SIGB 3,022,139 307,583 88.1 3,492
FIT + SIG 2,990,860 276,304 88.1 3,137
COL 2,906,228 191,672 86.7 2,211
CTC DoD 3D 6mm 5y 3,469,651 755,095 85.3 8,854
CTC NCTC 2D/3D 6mm 5y 3,489,227 774,671 81.3 9,526

ACER = average cost-effectiveness ratio compared with no screening; LYG = life-years gained compared with no screening; NA = not applicable; CS = cost-saving

Table A.3.2. Discounted costs and discounted life-years gained per 1000 65-year olds and average cost-effectiveness ratios, by CRC screening scenario – SimCRC

Scenario Discounted Costs, $ Net Discounted Costs, $ Discounted LYG ACER, $/LYG
No screening 2,367,514 0 0 NA
HII 2,082,788 -284,726 59.9 CS
HS 2,042,708 -324,806 81.1 CS
FIT 2,116,618 -250,896 79.8 CS
SIGB 2,168,782 -198,733 65.2 CS
SIG 2,151,925 -215,589 69.1 CS
HII + SIGB 2,085,889 -281,625 85.7 CS
HII + SIG 2,072,929 -294,585 87.0 CS
HS + SIGB 2,151,806 -215,708 92.5 CS
HS + SIG 2,150,786 -216,728 93.0 CS
FIT + SIGB 2,244,313 -123,201 92.3 CS
FIT + SIG 2,244,650 -122,864 92.8 CS
COL 2,173,712 -193,802 93.8 CS
CTC DoD 3D 6mm 5y 2,674,721 307,206 92.0 3,340
CTC NCTC 2D/3D 6mm 5y 2,706,113 338,599 87.2 3,881

ACER = average cost-effectiveness ratio compared with no screening; LYG = life-years gained compared with no screening; NA = not applicable; CS = cost-saving

Table A.3.3. Discounted costs and discounted life-years gained per 1000 65-year olds and average cost-effectiveness ratios, by CRC screening scenario – CRC-SPIN

Scenario Discounted Costs, $ Net Discounted Costs, $ Discounted LYG ACER, $/LYG
No screening 1,976,803 0 0 NA
HII 1,536,474 -440,329 64.0 CS
HS 1,482,449 -494,354 87.3 CS
FIT 1,574,679 -402,123 84.7 CS
SIGB 1,716,321 -260,482 75.8 CS
SIG 1,626,360 -350,443 80.4 CS
HII + SIGB 1,656,317 -320,486 92.9 CS
HII + SIG 1,590,434 -386,369 94.5 CS
HS + SIGB 1,666,766 -310,037 99.9 CS
HS + SIG 1,611,331 -365,472 100.5 CS
FIT + SIGB 1,768,508 -208,295 99.2 CS
FIT + SIG 1,699,373 -277,430 99.9 CS
COL 1,600,155 -376,648 105.5 CS
CTC DoD 3D 6mm 5y 2,156,740 179,938 101.2 1,777
CTC NCTC 2D/3D 6mm 5y 2,172,677 195,874 98.0 1,999

ACER = average cost-effectiveness ratio compared with no screening; LYG = life-years gained compared with no screening; NA = not applicable; CS = cost-saving

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